Periaqueductal Gray Matter Dysfunction in Migraine: Cause or the Burden of Illness?
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چکیده
منابع مشابه
Interictal alterations of the trigeminal somatosensory pathway and periaqueductal gray matter in migraine.
Migraine has been traditionally considered a nonprogressive, paroxysmal disorder with no brain abnormalities between attacks. We used diffusion tensor imaging to examine interictal diffusion properties of the brains of migraineurs with aura, migraineurs without aura and matched healthy controls. Areas of lower fractional anisotropy were present in migraineurs along the thalamocortical tract. In...
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Single unit activity was recorded extracellularly from the periaqueductal gray matter (PAG) and the superior colliculus of three monkeys during spontaneous saccades and fixation. Most saccade-related cells were found in the dorsal and lateral regions of the PAG and they paused with saccades. The pause preceded the onset of saccades by 34.5 +/- 6.8 msec (n = 31). In 90% of the 31 PAG cells, the ...
متن کاملMagnetic Resonance Image Texture Analysis of the Periaqueductal Gray Matter in Episodic Migraine Patients without T2-Visible Lesions
Objective The periaqueductal gray matter (PAG), a small midbrain structure, presents dysfunction in migraine. However, the precise neurological mechanism is still not well understood. Herein, the aim of this study was to investigate the texture characteristics of altered PAG in episodic migraine (EM) patients based on high resolution brain structural magnetic resonance (MR) images. Materials ...
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Human neuroimaging offers a powerful way to connect animal and human research on emotion, with profound implications for psychological science. However, the gulf between animal and human studies remains a formidable obstacle: Human studies typically focus on the cortex and a few subcortical regions such as the amygdala, whereas deeper structures such as the brainstem periaqueductal gray (PAG) p...
متن کاملComparing the analgesic effects of periaqueductal gray matter injection of orexin A and morphine on formalin- induced nociceptive behaviors.
Introduction: Orexin-A and B (Hypocretin 1 and 2) are neuropeptides that are mostly expressed in the posterior and lateral hypothalamus (LH). Intracisternal (ICV) and intratechal (IT) injections of orexin-A (hypocretin-1) have been shown to elicit analgesic responses in formalin test. However, the locations of central sites that may mediate these effects have not been clearly elucidated. Ore...
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ژورنال
عنوان ژورنال: Headache: The Journal of Head and Face Pain
سال: 2001
ISSN: 0017-8748,1526-4610
DOI: 10.1046/j.1526-4610.2001.041007629.x